126 Creation of a Humanized Model for Respiratory Allergy Using a Human Mugwort-specificT-Cell Receptor and HLA-DR1
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126 Creation of a Humanized Model for Respiratory Allergy Using a Human Mugwort-specificT-Cell Receptor and HLA-DR1
125 The Association betweenMast Cells andRemodelling of the Small Airways in Chronic Asthma Kenneth Snibson, PhD, and Joanne Van der Velden,. Veterinary Science, University of Melbourne, Parkville, Australia. Background: Repeated airway challenges with House Dust Mite (HDM) allergen results in marked remodelling and mast cell hyperplasia in the small airways of allergic sheep. We now examine ma...
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Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis
INTRODUCTION T cells orchestrate joint inflammation in rheumatoid arthritis (RA), yet they are difficult to study due to the small numbers of antigen-specific cells. The goal of this study was to characterize a new humanized model of autoimmune arthritis and to describe the phenotypic and functional changes that occur in autoimmune T cells following the induction of pathological events. METHO...
متن کاملHLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model.
NK cells use NK cell receptors to be able to recognize and eliminate infected, transformed, and allogeneic cells. Human NK cells are prevented from killing autologous healthy cells by virtue of inhibitory NKRs, primarily killer cell Ig-like receptors (KIR) that bind "self" HLA class I molecules. Individual NK cells stably express a selected set of KIR, but it is currently disputed whether the f...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2012
ISSN: 1939-4551
DOI: 10.1097/01.wox.0000411871.74126.3c